Kemgbe mmalite nke ọrịa na-efe efe, nnwale nyocha ekerewo òkè dị mkpa n'ịchịkwa mgbasa nke SARS-CoV-2, nje na-akpata.COVID 19.Nnwale antigen ngwa ngwaemere n'ụlọ ma ọ bụ na ọnọdụ ụlọ ọgwụ na-enye nsonaazụ na nkeji iri na ise ma ọ bụ obere.Ka a chọpụtachara mmadụ na mbụ, ngwa ngwa ha nwere ike ịchọ nlekọta ahụike wee kewapụ onwe ya na ndị ọzọ.Mana mgbe ụdị nje ọhụrụ pụtara, ule ndị a agaghị achọpụta ụdịdị ndị ahụ.
Emebere ule antigen kacha ngwa ngwa iji chọpụta protein SARS-CoV-2 nucleocapsid ma ọ bụ protein N-protein.A na-ahụ protein a n'ụba n'ime ụmụ irighiri nje na ndị nwere ọrịa.Ngwa ule ngwa ngwas na-enwekarị ọgwụ mgbochi ọrịa abụọ dị iche iche na-ejikọta n'akụkụ dị iche iche nke protein N.Mgbe ihe mgbochi na-ejikọta na protein N n'ime ihe nlele, eriri agba ma ọ bụ mgbama ọzọ na-apụta na ngwa ule, na-egosi ọrịa.
Protein N nwere ngalaba nhazi amino acid 419.Nke ọ bụla n'ime ha nwere ike iji amino acid ọzọ dochie ya site na ngbanwe.Otu nyocha nke Ph.D.Philip Frank na Eric Ortlund nke Mahadum Emory malitere inyocha ka otu mgbanwe amino acid a si emetụta arụmọrụ nke ule antigen ngwa ngwa.Ha jiri usoro a na-akpọ nyocha mmụgharị miri emi iji chọpụta n'otu oge ka mmụgharị ọ bụla dị na protein N nke nje si emetụta njikọ na mgbochi ọrịa.E bipụtara nsonaazụ ha na Cell na Septemba 15, 2022.
Ndị nyocha ahụ mepụtara ọbá akwụkwọ zuru oke nke ihe fọrọ nke nta ka ọ bụrụ 8,000 N ngbanwe protein.Ụdịdị ndị a nwere ihe karịrị 99.5% nke mmụgharị niile enwere ike.Ha tụlekwara ka ụdịdị nke ọ bụla si nwee ọgwụ mgbochi ọrịa 17 dị iche iche ejiri na nnwale antigen 11 dị ngwa ngwa, gụnyere ndị nkịtị.ngwa ụlọ.
Ndị otu ahụ nyochara mmụgharị protein N-protein na-emetụta njirimara mgbochi mmadụ.Dabere na ozi a, ha mepụtara “profaịlụ mmụgharị mgbapụ” maka ọgwụ mgbochi ọ bụla.Profaịlụ a na-achọpụta mmụgharị a kapịrị ọnụ na protein N nke nwere ike imetụta ikike mgbochi mgbochi ijikọ na ebumnuche ya.Nnyocha ahụ gosipụtara na ọgwụ mgbochi ndị a na-eji na nnwale ngwa ngwa taa na-amata ma jikọta ụdị SARS-CoV-2 niile gara aga na nke ugbu a nke nchegbu na nchegbu.
Ọ bụ ezie na ọtụtụ ọgwụ mgbochi ọrịa na-amata otu mpaghara nke protein N, ndị nyocha ahụ chọpụtara na ọgwụ mgbochi ọ bụla nwere mbinye aka pụrụ iche nke mgbanwe mgbapụ.Ka nje SARS-CoV-2 na-aga n'ihu na-agbanwe ma na-emepụta ụdị dị iche iche, enwere ike iji data a gosipụta ọgwụ mgbochi ngwa ule nke nwere ike ịchọ nyochaghachi.
Ortlund kwuru, "Nchọpụta ziri ezi na nke ọma nke ndị butere ọrịa ka bụ atụmatụ dị oke mkpa maka mbelata COVID-19, ọmụmụ anyị na-enye ozi gbasara mmụgharị SARS-CoV-2 n'ọdịnihu nke nwere ike igbochi nchọpụta," Ortlund kwuru."Nsonaazụ akọwapụtara ebe a na-enye anyị ohere ịmegharị ngwa ngwa na nje a ka ụdị ọhụrụ na-aga n'ihu na-apụta, na-egosipụta mmetụta ahụike na ahụike ọha ozugbo."
Ihe ndabere: Mmụba Deep Scan na-achọpụta mmụgharị mgbapụ na SARS-CoV-2 nucleocapsid site na iji nnwale antigen dị ugbu a.Frank F., Kin MM, Rao A., Bassit L., Liu H, Bowers HB, Patel AB, Kato ML, Sullivan JA, Greenleaf M., Piantadosi A., Lam VA, Hudson VH, Ortlund EA cell.2022 Septemba 15;185(19):3603-3616.e13.Ozi nke ime obodo: 10.1016/j.cell.2022.08.010.Ọgọst 29, 2022 PMID: 36084631.
Ego: National Institute for Biomedical Imaging and Bioengineering NIH (NIBIB), National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) na National Institute of Allergy and Infectious Diseases (NIAID), American Heart Association.
NIH Research Matters bụ mmelite kwa izu nke isi nchọpụta NIH nke ndị ọkachamara NIH nyochara.Ọ bụ ụlọ ọrụ mgbasa ozi na ọhaneze na-ebipụta ya nke onye isi ụlọ ọrụ ahụike mba.